Of note, somewhat higher expressions of E-cadherin and β-catenin have been reported in the metastatic prostate cancer cells that have already reached the bone (Saha et al., 2008[114]), suggesting that reverse, mesenchymal to epithelial transition (MET) is a prerequisite for the growth of metastatic cells at the site of a secondary bone deposit (Jin et al., 2011[63]). Here, CDH1 is linked to Familial prostate cancer.