CDH1 and Familial prostate cancer: Finally, considering the property of E-cadherin to bind to β-catenin and immobilize it, the increased expression of E-cadherin upon genistein application (15 μM/L, 24 h or 48 h) to prostate cancer cells may suggest some indirect benefits in impeding metastasis (Zhang et al., 2008[144]; Mahmoud et al., 2014[86]).