At this stage of prostate cancer progression, the expression of β-catenin also decreases (Jaggi et al., 2005[62]), all of which contributes to the loosening of connections between the cells, given the important role of E-cadherin and β-catenin complexes in the maintenance of cell-cell adhesions (Jin et al., 2011[63]). This evidence concerns the gene CDH1 and Familial prostate cancer.