CD4 and neoplasm: This point would give us an idea on whether EBI3 would contribute either to the immunosuppressive IL-35 or to the anti-tumour immune response as part of IL-27.9,13 In this analysis, we found a positive correlation between EBI3 and CD4 mRNA expression in the CTR region of patients with NSCLC (Fig. S4A, B) and in the PT region of the lung of patients with ADC but not in those with SCC (Fig. S4C, D).