EBI3 and non-small cell lung carcinoma: Furthermore, an interaction between EBI3 and p28 results in the formation of IL-27, whereas p35 in combination with p40 forms IL-12 (Fig. S2A).21 To investigate the regulation of IL-12 cytokine family members during NSCLC development, we next determined the expression of the different components in the TU, PT and CTR area obtained from patients who suffer from ADC and SCC (Fig. S2).