Furthermore, an interaction between EBI3 and p28 results in the formation of IL-27, whereas p35 in combination with p40 forms IL-12 (Fig. S2A).21 To investigate the regulation of IL-12 cytokine family members during NSCLC development, we next determined the expression of the different components in the TU, PT and CTR area obtained from patients who suffer from ADC and SCC (Fig. S2). This evidence concerns the gene EBI3 and AIDS dementia complex.