Macrophage chemoattractant chemokines MCP-1 (CCL2) and RANTES (CCL5): In a rat model of cancer and in human monocytes in vitro, Josephs and colleagues demonstrated, that IgE crosslinking triggered a TNFα/MCP-1 axis, which resulted in recruitment of macrophages into tumours [9]. The gene discussed is CCL5; the disease is cancer.