VEGF-A mediates its effects on endothelial cells predominantly via the receptor tyrosine kinase (RTK) VEGF receptor 2 (VEGFR2), which also represents an important drug target for cancer angiogenesis (Ferrara, 2009; Claesson-Welsh and Welsh, 2013, Peach et al., 2018a). The gene discussed is KDR; the disease is cancer.