The CREB protein is a crucial transcription factor that regulates a wide range of biological processes that orchestrate cell differentiation and cell growth.31 CREB enhances cell proliferation, reduces apoptosis sensitivity and increases angiogenesis and radiation‐induced differentiation.32 Overexpression of CREB was reported in many solid tumour types like breast cancer, liver cancer and melanoma when compared to adjacent normal tissues.33, 34 CREB is an important factor in cAMP signalling, which regulates protein levels by controlling gene transcription. This evidence concerns the gene CREB1 and liver cancer.