In this study, we aimed to explore the effect of RBM10 overexpression and knockdown on the proliferation of lung adenocarcinoma cells as well as the affected downstream pathways by assessing the expression of several regulatory proteins that have previously been identified as being modulated by RBM10.14 We then sought to verify the effect of RBM10 overexpression and inhibition in vivo in BALB/c mice. The gene discussed is RBM10; the disease is lung adenocarcinoma.