Western blotting revealed that the expression of phospho‐AKT and phospho‐CREB was remarkably changed in RBM10‐inoculated tumour tissues (Figure 4H).These results indicate that RBM10 functions as a tumour‐suppressing molecule and negatively regulates lung adenocarcinoma cell growth in vivo. The gene discussed is CREB1; the disease is lung adenocarcinoma.