Liver‐specific PTPN2 deficiency led to the development of metabolic syndrome.13, 15 Consisting with these studies, our results suggested that PTPN2 overexpression ameliorated hyperglycaemia and improved serum levels of triglyceride, total cholesterol and LDL‐cholesterol in HF/STZ‐induced diabetic mice, further uncovering the biological function of PTPN2 in metabolism modulation. Here, PTPN2 is linked to metabolic syndrome.