PTPN2 gene therapy significantly suppressed VEGF expression and angiogenesis in diabetic mice. The immature structure and function of neo‐vascular increase glomerular filtration barrier and elevate permeability, resulting in 24‐hour proteinuria, glomerular sclerosis, interstitial fibrosis by promoting extracellular matrix deposition.34, 39. The gene discussed is VEGFA; the disease is glomerulosclerosis.