Evidence is emerging for the involvement of PTPN2 in inflammatory diseases (eg Crohn's disease, T1DM and rheumatoid arthritis).16, 24, 31 Consistent with these results, we demonstrated that PTPN2 suppressed renal injury and fibrosis via down‐regulation of pro‐inflammatory cytokines and subsequent lymphocytes influx. This evidence concerns the gene PTPN2 and type 1 diabetes mellitus.