CXCR4 exclusively colocalized with neuronal cells in the Plantar incision‐induced postsurgical pain.26 But, CXCR4 was predominantly localized to the astrocytes and microglia in a rat model of ischemia/reperfusion‐induced inflammatory pain.10 In our study, SNL induced notable increase of CXCR4, which was predominantly in the neurons and astrocytes of the spinal dorsal horn. This evidence concerns the gene CXCR4 and ischemia.