C5AR1 and acute myeloid leukemia: Our previous study showed that LukS‐PV can induce apoptosis and inhibit proliferation in AML THP‐1 and HL‐60 cells, and in vivo studies have shown that LukS‐PV has no obvious side effects.15 C5aR is a receptor for PVL, LukS‐PV specifically binds to receptors on the plasma membrane of polymorphonuclear leukocytes and then combines with LukF‐PV to form an octamer that plays a key role in membrane perforation.