The importance of the endocytic pathway in PD pathology has been highlighted by previous work with LRRK2 but also other disease causing mutations in genes such as VPS35, DNAJC6, SYNJ1, GAK and Rab7L1 (Elsayed et al., 2016; Krebs et al., 2013; Nalls et al., 2014; Olgiati et al., 2016; Vilariño-Güell et al., 2011; Zimprich et al., 2011). Here, LRRK2 is linked to Parkinson disease.