Another study showed that ARVD-hiPSC-CM directly transdifferentiate into adipocytes when cultured in a similar lipogenic medium (+insulin, dexamethasone, IBMX and indomethacin), suggesting a possible mechanism of the well-known fibroadipocytic replacement of cardiac myocytes in ARVD [131]. The gene discussed is INS; the disease is arrhythmogenic right ventricular cardiomyopathy.