Recent studies have shown that epiegulin-, MMP-13-, ICAM-1- or TSP-1-enriched exosomes could strengthen the release of vascular endothelial growth factors (VEGF-A, FGF-2, IL-8) and then downregulate junction-related proteins (claudins and ZO-1) that promote tumor angiogenesis and vascular permeability, becoming a potential passway system for distant metastasis of tumor cells [70, 71, 73, 98]. This evidence concerns the gene VEGFA and neoplasm.