SREBF1 and hepatocellular carcinoma: So we silenced SREBP-1c, the transcription factor controlling fatty acid synthesis, in HepG2 cells of the human hepatocellular carcinoma cell line, then we cultured these HepG2 cells in normal growth medium or treated by a high level of FFA to observe the influence of SREBP-1c silencing on glucose production in HepG2 cells as well as the expression of genes related to lipid metabolism and gluconeogenesis.