TNF and Parkinson disease: Interestingly, the multimarker panel, IFNγ, IL-10 and TNFα performed well above the minimum SE/SP values (83.3 and 80.4%) compared to controls for early PD (< 1 year of symptom onset) that gradually shifted to IFNγ, IL-10 and NOx (SE = 93.3% and SP = 87.5%) for late PD (1–3 years and 3–12 years of PD) depicting the discriminatory value of TNFα and NOx in early and late PD (Table 3; Fig. 3 (a),(b), (c)).