NFKB1 and Parkinson disease: Additionally, outcomes of the current study may provide evidence on peripheral dysregulation in the cytokine network of the immune system in PD, which renders the possibility of manipulating the cytokine network to devise novel approaches to treat PD by targeting to block the cytokine synthesizing pathways that are involved in microglial and astrocyte activation such as NF-κB and JAK-STAT pathways.