CCT241736 exhibited anti-proliferative activity against HCT116 (human colon carcinoma), MOLM-13 and MV4-11 (human FLT3-ITD positive AML) cell lines, as well as strong inhibition of tumour growth in an MV4-11 xenograft mouse model (Bavetsias et al., 2012). The gene discussed is FLT3; the disease is acute myeloid leukemia.