Our data provide new insights into the pathogenicity of acute autoantibody exposure in anti-CNTN1-associated neuropathy and extend recent findings that were obtained by a study from Manso et al.: by modelling chronic autoantibody exposure using intravenous application, they demonstrated a pathogenic effect of IgG4 anti-CNTN1, leading to exacerbation of neuropathy in animals immunised with P2 protein [2]. This evidence concerns the gene CNTN1 and neuropathy.