G0S2 and chronic myelogenous leukemia, BCR-ABL1 positive: In a chronic myeloid leukemia cell line, K562, G0S2 gene was found to be silenced by gene methylation, and upregulation of G0S2 expression by retroviral transduction or treatment with 5-azacytidine inhibited the proliferation of K562 cells both in vitro and in a xenograft model [42].