PD-linked mutations in ATP13A2 lead to several lysosomal alterations in patient-derived fibroblasts, including impaired lysosomal acidification, decreased proteolytic processing of lysosomal enzymes, reduced degradation of lysosomal substrates, and diminished lysosomal-mediated clearance of autophagosomes [122]. Here, ATP13A2 is linked to Parkinson disease.