Here, IHC also confirmed that FOXO3 expression was lower in ccRCC tissues than in normal renal tissues (Fig. 6d), which was correspond with the Kaplan–Meier survival analysis from TCGA KIRC datasets that ccRCC patients with high FOXO3 expression had longer survival times than patients with low FOXO3 levels (Log-rank test, p < 0.001, Fig. 6e, Additional file 14: Table S10). The gene discussed is FOXO3; the disease is nonpapillary renal cell carcinoma.