However, we interpret this result cautiously because, unlike in the melanoma cell line dataset, IL32 expression in the melanoma tumor microenvironment did not inversely correlate with pigmentation or melanoma differentiation genes such as MLANA, TYR or PMEL. Thus, the high AXL/low MITF signature may be a result of increased IL32 expression by infiltrating immune cells, rather than IL32 expressing dedifferentiated melanoma cells in the tumor microenvironment. The gene discussed is PMEL; the disease is neoplasm.