TYR and melanoma: Furthermore, among the top 20 differentially expressed genes in melanoma cell lines in the lowest quartile of IL32 expression (compared to top quartile), we identified enrichment of genes related to pigmentation and melanogenesis (TYR, MLANA, PMEL, TYRP1, DCT, and MITF; hypergeometric p-value = 7.9 × 10−15).