SLC5A2 and heart failure: Overall, the diuretic effect of SGLT2 inhibitors seems to be most effective during the initial period of SGLT2 inhibition [38], and we showed that it causes changes in fluid status and could therefore be responsible for fast acting beneficial effects on heart failure; reduction of adipose tissue that we confirmed in the follow up period of SGLT2 inhibition indicates that additional mechanisms for risk reduction in heart failure could gain importance in the long term course, such as lipid utilization [31], reduction of epicardial fat [32, 33], and effects on vascular endothelial function [50].