After the co-transfection of miR-502-5p inhibitor and si-NRAS in MKN-28 cells or miR-502-5p mimic and NRAS in BGC-823 cells, we found that, knockdown of NRAS inhibited the cell proliferation and invasion, and abrogated the tumor-promoting effects of miR-502-5p inhibitor (P < 0.05, Additional file 10: Figure S9B, D), while ectopic expression of NRAS showed the opposite effects (P < 0.05, Additional file 10: Figure S9C, E). This evidence concerns the gene NRAS and neoplasm.