HPC2 staining was observed in 80% (48/60) of pancreatic cancers and 32% (10/31) of cholangiocarcinomas; whereas, N-cadherin stained 27% (16/60) of the pancreatic cancers and 58% (18/31) of cholangiocarcinomas. Here, CDH2 is linked to familial pancreatic carcinoma.