We plan to broaden the currently conducted research topic with the study of “molecular parameters”: slowly circulating cellular DNA (coding sequence of Neudesin, Nogo-A, IL-8, CCL2, and sICAM-1 genes) in cerebrospinal fluid/serum, mRNA level for the above proteins in peripheral blood cells (granulocytes/PBMC) and tissues of brain tumors. This evidence concerns the gene RTN4 and brain neoplasm.