And this finding agrees with previous results that rutaecarpine attenuates isoprenaline‐ and AAC‐induced pathological cardiac hypertrophy.9, 41 In addition, we revealed that rutaecarpine inhibited the Nox4‐ROS‐ADAM17 pathway in the left ventricle of AAC‐induced hypertensive rats and primary cardiomyocytes stimulated with Ang II. This evidence concerns the gene ADAM17 and cardiac hypertrophy.