Combined with the important role of the TLR/MyD88 downstream molecules IRF5, AP1, and NF‐κB in M1 macrophage polarization, we deduced that CTRP9 also affected macrophage polarization to participate in post‐MI protective effects via the TLR4/NF‐κB pathway. This evidence concerns the gene IRF5 and myocardial infarction.