However, the mean expression levels of circulating miR-504 in ALK-positive patients (11.41 for miR-191 normalised data; 15.38 for miR-16 normalised data) were clearly lower than in EGFR-mutated subjects (13.24 and 17.01, respectively), which is consistent with the trend observed in tumour tissue. This evidence concerns the gene ALK and neoplasm.