It reported that other Reg members Reg1 and Reg3 expression couldbe enhanced by several cytokines, such as IL-6.28–30 In contrast to Reg1 or Reg3expression, proinflammatory cytokines had none stimulatory effect on Reg4 gene expression in the human colon cancer cellline.24 It thus suggests that the Reg4 gene expression is cannot be directly stimulatedby cytokines. Here, IL6 is linked to colonic neoplasm.