In humans the intestinally induced IgA anti-LPS and anti-CTB antibody responses as measured in intestinal lavage fluid have correlated closely to the protective efficacy of cholera vaccines.37–39 Even though vaccine-induced protection against intestinal V. cholerae infection cannot be measured in immunocompetent adult mice, our findings would strongly suggest that such adjuvantation if achievable with α-GalCer and SmPill® in humans could benefit the protective immunogenicity of OCVs. The gene discussed is CD79A; the disease is vibrio infectious disease.