miR-200 family members are down-regulated and play a critical role in the control of epithelial-to-mesenchymal transition (EMT); miR-34a, one of the best described p53-regulated miRNA, contributes to tumor suppression by inhibiting cellular proliferation and survival; down-regulation of let-7a, let-7e, let-7f, some of let-7 family members, is associated with aggressive behaviour of tumor and represents potential markers of invasion and metastasis in EOC12–14. The gene discussed is TP53; the disease is neoplasm.