IRS2 and Hyperinsulinemia: Considering the cross-talk among several pathways, and the hormones and the cytokines implicated in the IRS2 null mice (i.e., hyperinsulinemia in male, and adipocyte-derived hormones as leptin or oestrogens in female), the findings observed in the thyroid follicles of this diabetic phenotype could most likely be multifactorial.