EGFR and non-small cell lung carcinoma: Osimertinib, a next-generation EGFR TKI, is approved in the US for the treatment of patients with EGFR T790M mutation-positive inoperable or recurrent NSCLC that is resistant to EGFR TKI therapy, and for the first-line treatment of patients with inoperable or recurrent EGFR mutation-positive NSCLC.