Indeed, the work of Tsuji et al. showed that the concentration of YKL-40 was more elevated in the degenerative spine disease group with values of 245.3 ± 107.2 ng/ml in cervical myelopathy, 143.2 ± 53.6 ng/ml in lumbar disc herniation, 241.5 ± 77.2 ng/ml in lumbar canal stenosis. The gene discussed is CHI3L1; the disease is lumbar disc herniation.