Interestingly, they showed that YKL-40 levels in patients with scoliosis (71.4 ± 33.9 ng/ml) was significantly lower (P < 0.001) when compared to other spine diseases or even the control group (113.8 ± 48.3 ng/ml), which is in agreement with our data. This evidence concerns the gene CHI3L1 and scoliosis.