For example, expression of PPARγ target genes is specifically induced in adipocyte-specific NCoR1-knockout mice, which exhibit increased insulin sensitivity in liver, fat, and muscle, and develop obesity and expansion of fat tissue on a high-fat diet due to an increase in the number of small adipocytes and reduced inflammation in adipose tissue57. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.