Of the five variants associated with sleep efficiency, a measure of sleep quality, one was the strongly associated PAX8 sleep duration signal11 (rs62158169, P = 2 × 10−8) and one was a restless legs syndrome/insomnia-associated signal (MEIS1)18,35 (rs113851554, P = 5 × 10−22). The gene discussed is PAX8; the disease is insomnia.