PDE11A and congenital adrenal hyperplasia: Protein truncating variants in PDE11A have been suggested to cause adrenal hyperplasia;48 however, one of these variants (R307X, rs76308115) is present at 0.5% frequency in the UK Biobank (with 11 rare allele homozygotes) and is not associated with sleep efficiency (P = 0.99) or duration (P = 0.54).