Interestingly, Lico A treatment not only dramatically suppressed the expressions of Txnip, NLRP3, ASC, Cleaved-caspase-1, and Mature-IL-1β protein (Fig. 5), but also enhanced the expression Trx-1 protein in LPS/GalN-induced ALI, implying that inflammation inhibited by Lico A may also be partly responsible for suppressing activation of the Txnip-NLRP3 inflammasome. Here, TXNIP is linked to acute respiratory distress syndrome.