MYC and cancer: For example, it was later demonstrated that cancer cells overexpressing Myc fuel tumour growth by eliminating the surrounding healthy cells (de la Cova et al., 2004; Moreno and Basler, 2004), whereas Myc mutant cells (Johnston et al., 1999) or cancer cells bearing mutations in polarity genes are outcompeted by their wild-type neighbours, resulting in tumour suppression (Brumby and Richardson, 2003).