Accordingly, in our OSAHS patient sample, increasing serum irisin level by 1 ng/mL fails to cause a significant increase of the ESS score if serum BDNF levels are in the lower range (e.g. below 280 ng/mL), indicating that low irisin levels have a small, nonsignificant effect on BDNF levels and consequently on ESS score. The gene discussed is BDNF; the disease is obstructive sleep apnea syndrome.