However, alteration of the circadian rhythm in OSAHS has been established previously [37], allowing the speculative notion that altered irisin/BDNF axis may be causative for circadian misalignment in OSAHS, and thus, it may be suggested that excessive daytime sleepiness is a result of the deterioration of circadian pacemaker process. This evidence concerns the gene BDNF and obstructive sleep apnea syndrome.