AARS2 and cardiomyopathy: AARS2 c.1774 C>T (p.R592W) is a common missense founder mutation, found in nearly all AARS2-associated clinically fatal early onset cardiomyopathies, except our two recently identified patients with cardiomyopathy with AARS2 c.1738C>T (p.R580W) mutations (43,45,49).