In results, aucubin inhibited hyperlipidaemia, oxidative stress and inflammation by influencing the content of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), myeloperoxidase (MPO), superoxide dismutase (SOD), tumour necrosis factor receptor‐α (TNF‐α), interleukin‐1β (IL‐1β), and IL‐6 in blood. This evidence concerns the gene SOD1 and hyperlipidemia.