Recently, ubiquitin‐proteasome system (UPS) proteins, E3 ligases and deubiquitylation enzymes (DUBs) were found to play important roles in the development of cardiac hypertrophy (Figure 1; Table 3).42 Studies found that K63‐linked polyubiquitination of TAK1 triggered by the E3 ligase, TRIM8, leads to pathological hypertrophy. The gene discussed is TRIM8; the disease is cardiac hypertrophy.