OGT and cardiac hypertrophy: Cardiomyocyte‐specific deletion of OGT is characterized by cardiac hypertrophy in adult mice, suggesting that decreasing O‐GlcNAcylation induces hypertrophy development.86 However, emerging studies show that an increase in O‐GlcNAc levels was observed in pathological cardiac hypertrophy in the mice hearts induced by phenylephrine treatment.87, 88 Therefore, according to current reports, we cannot get a definite conclusion whether O‐GlcNAcylation induces or attenuates hypertrophy development and heart failure.