The Database of Genomic Variants (DGV), which contains genomic variations observed in healthy individuals (http://genome.ucsc.edu and http://projects.tcag.ca/variation/) reports one additional contiguous deletion of LRP6 and ETV6, several separate small deletions of LRP6 and ETV6 and one extended deletion of LRP6. One might hypothesize that in these healthy individuals the associated tooth agenesis and thrombocytopenia are not identified as congenital malformations or the features are subclinical. This evidence concerns the gene LRP6 and Thrombocytopenia.