This study proposed three novel NPC subcategories based on gene sets with somatic SNVs, indels, and CNVs: (a) an unclassified subgroup, (b) a cell‐cycle subgroup, and (c) a RAS/PI3K/AKT subgroup, revealing that different mutagenic processes are operative through NPC development. The gene discussed is PIK3CA; the disease is nasopharyngeal carcinoma.