Notably, six NPC patients with lymph node metastasis harbored SOX4 amplifications, which is involved in the Wnt signaling pathway (Figure 3D) and consistent with a previous study,26 demonstrating that SOX4 amplification was associated with lymph node metastasis and highly enriched in advanced‐stage NPC. Here, SOX4 is linked to metastatic malignant neoplasm in the lymph nodes.