As shown in Figure 3D, up‐regulation of E‐cadherin and down‐regulation of N‐cadherin, Vimentin and Snail were detected upon ZEB2‐AS1 knockdown, which suggested inhibition of EMT following ASO‐ZEB2‐AS1 introduction in HNSCC cells. This evidence concerns the gene VIM and head and neck squamous cell carcinoma.