Several lncRNA such as HOTAIR, H19 and DLEU1 have been revealed to facilitate initiation and progression of HNSCC and their overexpression serve as diagnostic and prognostic biomarkers.11, 12, 13 However, quite few NATs have been identified as key oncogene or tumour suppressor in HNSCC thus far. This evidence concerns the gene H19 and head and neck squamous cell carcinoma.