Previous reports have delineated that ZEB2‐AS1 is aberrantly up‐regulated in several types of human cancer and associated with tumour aggressiveness and unfavourable prognosis.16, 17 For example, overexpression of ZEB2‐AS1 significantly correlated with tumour size, lymph node metastasis and tumour stage in bladder cancer.14 Consistent with these findings, our results from HNSCC cell lines and primary samples indicated that ZEB2‐AS1 was significantly elevated in a fraction of HNSCC as compared to their counterparts. This evidence concerns the gene ZEB2 and neoplasm.