Additionally, our findings from primary HNSCC samples and cell lines revealed higher expression of ZEB2 in HNSCC relative to their non‐tumour counterparts and the positive correlation between ZEB2‐AS1 and ZEB2 in HNSCC primary samples (Pearson correlation analysis, R = 0.9059; P < 0.0001; Figure S4A‐C) and cell lines (R = 0.8536, P = 0.0029; Figure S4D,E). This evidence concerns the gene ZEB2 and head and neck squamous cell carcinoma.