Indeed, some previous reports have offered vital clues regarding ZEB2‐AS1 in modulating ZEB2 expression in diverse contexts.24, 25 As shown in Figure 4A‐C, ASO‐ZEB2‐AS1 treatment resulted in significant down‐regulation of ZEB2 mRNA and protein in both HNSCC cells. This evidence concerns the gene ZEB2 and head and neck squamous cell carcinoma.