Recently the mechanism of uropod formation was described, as the triggering event is cell polarization by chemotaxis molecules.37 SDF‐1 regulates adhesion, motility and cell shape in tumour progression.38 They described morphological changes from round to polygonal shape, including the formation of neurite‐like projections, increased membrane ruffling, and more frequent filopodia and uropod formation in response to SDF‐1. Here, CXCL12 is linked to neoplasm.