POU5F1 and neoplasm: In addition to that, we also looked into the expression of β‐catenin and Oct4, which are core molecules in Wnt‐mediated stem cell signalling.19 Oct4 showed significantly increased nuclear expression in tumour and distal tissues compared to normal tissue with a mean percentage of cells (34.91 ± 9.74, P = 0.0445) and (26.48 ± 5.42, P = 0.0329) vs (8.749 ± 3.43) respectively (Figure 3G).