This heterogeneity in abundance of CSCs in tumor and distal tissues could have significant clinical importance as Ep‐CAM+/CD44+ cells are invasive in nature and possess higher metastatic potential.14 Therefore, the presence of these cells at distal margin raises the concern for the presence of invasive cancer cells, which could lead to distant metastasis if left unidentified. The gene discussed is EPCAM; the disease is neoplasm.