We propose that studying active transcription factor‐miRNA transcriptional regulatory networks, such as STAT3‐miRNA networks, in specific vascular endothelial cell types can help further elucidate the regulation of miRNAs, the gene networks and the cellular pathways between angiogenesis and atherosclerosis and perhaps lead to the development of pharmacologically novel therapeutic approaches for improved antiangiogenic strategies to prevent the progression and instability of atherosclerotic plaques. The gene discussed is STAT3; the disease is atherosclerosis.