Furthermore, latest experiment investigating the effects of B.  infantis administration in CRC rat model demonstrated a considerable attenuation of chemotherapy-induced intestinal mucositis correlated with decreased level on proinflammatory cytokines (IL-6, IL-1β, TNF-α) and increased CD4+ CD25+ Foxp3+ T regulatory cell response [71]. This evidence concerns the gene CD4 and colorectal carcinoma.