GK and Hyperglycemia: Altogether, we conclude that the E3L.GK+/− mouse is a promising translatable diet-inducible model, combining dyslipidemia and hyperglycemia with human-like plasma cholesterol and glucose levels and aggravated atherosclerosis, to study the etiology of diabetic atherosclerosis and for the evaluation of lipid-lowering and antidiabetic drugs and their combination thereon.