IGF-1 transgenic overexpression not only activates survival signaling pathways in the cardiomyocytes, but also mediates myocardial repair by modulating the inflammatory response post-MI with decreased expression of the pro-inflammatory cytokines IL-1β and IL-6 and increased expression of the anti-inflammatory IL-4 and IL-10 compared to wild type mice (154). The gene discussed is IL10; the disease is myocardial infarction.