This ESC-like population expresses components of the renin-angiotensin system (RAS): pro(renin) receptor (PRR), angiotensin converting enzyme (ACE), angiotensin II receptor 1 (ATIIR1), and angiotensin II receptor 2 (ATIIR2) in the microvessels in this tumor (18). Here, REN is linked to neoplasm.